KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A3
All Species:
17.27
Human Site:
S135
Identified Species:
31.67
UniProt:
Q02108
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02108
NP_000847.2
690
77452
S135
P
V
E
V
I
K
E
S
L
G
E
E
V
F
K
Chimpanzee
Pan troglodytes
XP_522169
734
81883
R174
K
F
E
E
I
Q
E
R
F
G
E
E
F
F
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
R186
K
F
E
E
I
Q
E
R
F
G
E
E
F
F
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
S135
P
V
E
A
L
K
D
S
L
G
E
E
L
F
K
Rat
Rattus norvegicus
P19686
690
77548
S134
P
V
E
V
L
K
D
S
L
G
E
E
L
F
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510214
690
77963
S135
P
V
D
I
L
K
A
S
L
G
E
E
L
F
K
Chicken
Gallus gallus
XP_420375
688
77848
S133
P
V
E
S
L
R
E
S
L
G
E
E
L
F
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
E117
D
E
Q
K
C
L
F
E
N
S
R
C
D
S
Q
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
A141
Q
M
D
T
L
R
V
A
L
G
E
E
L
F
N
Fruit Fly
Dros. melanogaster
Q07093
676
75644
G128
L
I
T
C
C
C
T
G
I
I
E
R
A
F
R
Honey Bee
Apis mellifera
NP_001011650
699
78655
G144
S
T
F
F
D
Q
L
G
Q
E
V
I
Y
T
A
Nematode Worm
Caenorhab. elegans
O02298
688
78384
P145
S
K
R
S
G
L
Y
P
I
V
K
G
V
V
R
Sea Urchin
Strong. purpuratus
P16065
1125
126238
A379
A
S
V
Y
M
F
D
A
T
M
Q
L
L
E
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
N.A.
47.3
N.A.
89.5
89.2
N.A.
87.5
84
N.A.
39.1
58.9
34.2
35
29.5
22.6
Protein Similarity:
100
63
N.A.
62.4
N.A.
94.9
94.9
N.A.
93.4
92.3
N.A.
54.3
73.6
53.3
55.3
48.2
36.3
P-Site Identity:
100
46.6
N.A.
46.6
N.A.
73.3
80
N.A.
66.6
73.3
N.A.
0
33.3
13.3
0
6.6
0
P-Site Similarity:
100
53.3
N.A.
53.3
N.A.
93.3
100
N.A.
93.3
93.3
N.A.
13.3
73.3
33.3
6.6
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
0
0
8
16
0
0
0
0
8
0
16
% A
% Cys:
0
0
0
8
16
8
0
0
0
0
0
8
0
0
0
% C
% Asp:
8
0
16
0
8
0
24
0
0
0
0
0
8
0
0
% D
% Glu:
0
8
47
16
0
0
31
8
0
8
70
62
0
8
0
% E
% Phe:
0
16
8
8
0
8
8
0
16
0
0
0
16
70
0
% F
% Gly:
0
0
0
0
8
0
0
16
0
62
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
8
24
0
0
0
16
8
0
8
0
0
0
% I
% Lys:
16
8
0
8
0
31
0
0
0
0
8
0
0
0
39
% K
% Leu:
8
0
0
0
39
16
8
0
47
0
0
8
47
0
0
% L
% Met:
0
8
0
0
8
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
24
% N
% Pro:
39
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
8
0
8
0
0
24
0
0
8
0
8
0
0
0
8
% Q
% Arg:
0
0
8
0
0
16
0
16
0
0
8
8
0
0
16
% R
% Ser:
16
8
0
16
0
0
0
39
0
8
0
0
0
8
0
% S
% Thr:
0
8
8
8
0
0
8
0
8
0
0
0
0
8
0
% T
% Val:
0
39
8
16
0
0
8
0
0
8
8
0
16
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _